Molecular mechanism and physiological roles of the formation and maintenance of nucleosome by circadian regulator.

生物钟构成了无处不在的过程，以24小时为周期调节各种生化和生理事件。这些昼夜节律的紊乱可能是多种疾病的原因。这种节律的确切时间是在细胞自主分子钟中确定的，在哺乳动物中，转录因子BMAL1是分子钟的重要调节因子。本研究提供了几条证据，表明BMAL1可能在特定组蛋白（即组蛋白H3.3）沉积的动态变化中起重要作用。

Circadian clocks constitute ubiquitous processes that regulate various biochemical and physiological events occurring with a 24 hour periodicity. Dysfunction of these circadian rhythms can be the cause of a variety of diseases. The exact timing of this rhythm is established in cell-autonomous molecular clocks, and in mammals, the transcription factors, BMAL1, is an essential regulator of molecular clock. This study provides several lines of evidence indicating that BMAL1 may have important roles in dynamic changes ofdeposition of the specific histone, namely histone H3.3.