Screening of food factors inducing regulatory B cells

建立了一种筛选促进小鼠B细胞向调节性B细胞分化或激活调节性B细胞的黄酮类化合物的实验系统。利用这个系统，我们发现山奈酚和他马西丁在脂多糖存在的情况下上调白细胞介素-10产生的调节性B细胞。山奈酚可增加小鼠脾脏和肠系膜淋巴结中调节性B细胞的比例。山奈酚和他玛西汀对芳烃受体具有拮抗作用，可能与调节性B细胞的上调有关。本研究展示了一种针对调节性B细胞开发抗过敏和抗炎功能食品的新方法。

An experimental system screening flavonoids that enhance the differentiation of mouse B cells to regulatory B cells or those activating regulatory B cells was established. Using this system, we found that kaempferol and tamarixetin upregulated interleukin-10 -producing regulatory B cells in the presence of lipopolisaccharides. Oral administration of kaempferol was found to increase the ratio of regulatory B cells in spleens and mesenteric lymph nodes of mice. Kaempferol and tamarixetin showed an antagonistic activity to aryl-hydrocarbon receptor, and the activity was suggested to contribute to the up-regulation of regulatory B cells. This study demonstrates a novel approach to develop anti-allergic and anti-inflammatory functional foods targeting regulatory B cells.