Functional analysis and application of glutathiolated plant products

我们已经研究了Toll样受体（TLR）信号转导抑制潜力的食物来源的小分子。基于对芸苔属蔬菜提取物的TLR抑制活性的广泛筛选，我们发现卷心菜是最丰富的来源，并鉴定了3-（甲基亚磺酰基）丙基异硫氰酸酯（伊贝林），一种从西兰花中分离的萝卜硫素类似物，作为卷心菜中主要的TLR抑制剂之一。我们还研究了伊贝林的谷胱甘肽化和蛋白质反应性。

We have investigated the Toll-like receptor (TLR) signaling inhibitory potential of food-derived small molecules. Based on an extensive screening of Brassica vegetable extracts for the TLR-inhibitory activity, we found cabbage as the richest source and identified 3-(methylsulfinyl)propyl isothiocyanate (iberin), an analogue of sulforaphane isolated from broccoli, as one of the major TLR inhibitor in cabbage. We also studied glutathiolation and protein reactivity of iberin.