Fundamental study for the standardization of gastrointestinal endoscopy biopsies

本研究旨在规范犬和猫炎症性肠病（IBD）和低度恶性淋巴瘤的病理诊断标准，并阐明IBD和低度恶性淋巴瘤的病理学特征。 疾病的发病机制。在兽医中心、东京大学、日本动物转诊医疗中心（JARMeC）和日本小动物医疗中心（JSAMC），采用相同的程序和病理学家制备并诊断接受内窥镜检查的猫和犬蛋白质丢失性肠病的活检样本。 分别分析其病理诊断与临床预后的关系、基因克隆性检测、T/NK细胞分布模式及各种分子标志物的表达。本研究为IBD的内镜活检病理诊断提供了标准化指标，并揭示了IBD发病与低度恶性淋巴瘤的密切关系。

The aim of the study is to standardize the pathologic diagnostic criteria of canine and feline inflammatory bowel disease (IBD) and low grade lymphoma, and to elucidate the pathogenesis of the diseases. In Veterinary medical center, the University of Tokyo, Japan animal referral Medical Center (JARMeC), and Japan small animal Medical Center (JSAMC), the biopsy samples of feline and canine protein losing enteropathy admitted conducted endoscope, were prepared and diagnosed with identical procedures and pathologists. The relationship between pathological diagnoses and clinical prognosis, gene clonality tests, T/NK cells distribution patterns, and the expression of various molecular markers were investigated, respectively. Present study provided the standardized indicators of endoscopic biopsy pathology diagnosis, and also revealed the close correlation between pathogenesis of IBD and low grade lymphoma.