Roles of cell fusion in tissue regeneration and tumorigenesis

我们分析了小鼠组织中GCM1、SynA和SynB基因的表达，这些基因已知在胎盘形成过程中调节细胞融合。我们发现GCM1和SynA在除胎盘外的多个组织中均有表达，包括脑、肺、肝、肠、皮肤和肾脏。这一发现表明GCM1和SynA也参与了这些组织的细胞融合。接下来，我们研究了GCM1、SynA和SynB是否参与损伤组织修复和再生过程中的细胞融合。我们发现GCM1、SynA和SynB在肾缺血再灌注损伤中表达明显上调。在溃疡性结肠炎损伤的肠隐窝中，SynA的表达也增加。这些结果表明，GCM1、SynA和SynB在损伤组织修复和再生过程中诱导细胞融合。我们的发现可能有助于保护移植器官免受缺血再灌注损伤。

We analyzed expression of GCM1, SynA and SynB, genes that are known to regulate cell fusion during placentation, in mouse tissues. We found that GCM1 and SynA are expressed several tissues besides placenta, including the brain, lung, liver, intestine, skin and kidney. This finding suggests that GCM1 and SynA are also involved in cell fusion in these tissues. We next examined whether GCM1, SynA and SynB are involved in cell fusion during repair and regeneration of injured tissues. We found that expression of GCM1, SynA and SynB are markedly up-regulated in the kidney injured by ischemia-reperfusion. Expression of SynA is also increased in the crypt of the intestine injured by ulcerative colitis. These results suggest that GCM1, SynA and SynB induce cell fusion during repair and regeneration of injured tissues. Our findings may contributes to protection of the transplanted organ from ischemia-reperfusion injury.