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Genetic polymorphisms to analyze and predict treatment-related adverse effects in children with acute lymphoblastic leukemia

Genetic polymorphisms to analyze and predict treatment-related adverse effects in children with acute lymphoblastic leukemia
基因多态性分析和预测急性淋巴细胞白血病儿童治疗相关不良反应
批准号：
20790135
负责人：
NAKAMURA Tsutomu
金额：
$2.66万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790135/
关键词：
オーダーメード医療小児白血病遺伝子多型

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中文摘要
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英文摘要
Some children with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LBL) experience clinically important treatment-related adverse effects. In the present study, to identify novel potential loci influencing the risk of treatment-related hepatotoxicity during the maintenance phase, a genome-wide genotyping analysis was performed in Japanese children with ALL or LBL. Genome-wide genotyping uncovered a total of 28 candidate SNPs. rs1966862, in Rho GTPase-activating protein 24 (ARHGAP24), was the most significant of the candidates, and the genotypes of rs7403531 (RASGRP1) and some genes were also significantly associated with severe hepatotoxicity. This study suggested rs1966862 (ARHGAP24) and the other SNPs to be predictive factors for drug-induced hepatotoxicity during the maintenance phase in pediatric patients with ALL or LBL.
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Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles
ABCB1 3435C>T基因型对正常月经周期女性血清皮质醇和醛固酮水平的影响
DOI： --
发表时间： 2009
期刊： Genet Mol Res. 8
影响因子： --
作者： [A.Kuwahara, T.Nakamura, 他, Tsutomu Nakamura]
通讯作者： Tsutomu Nakamura
Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells
DOI： 10.1016/j.ejps.2009.01.009
发表时间： 2009-05-12
期刊： EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
影响因子： 4.6
作者： [Yamasaki, Daisuke, Nakamura, Tsutomu, Sakaeda, Toshiyuki]
通讯作者： Sakaeda, Toshiyuki
Genetic polymorphisms associated with hepatotoxicity in patients with Japanese childhood leukemia.
与日本儿童白血病患者肝毒性相关的基因多态性。
DOI： --
发表时间： 2008
期刊：
影响因子： --
作者： [M.Horinouchi, T.Nakamura, 他]
通讯作者： 他
食道癌化学放射線療法における患者個別化への取り組み
食管癌放化疗患者个体化的努力
DOI： --
发表时间： 2009
期刊：
影响因子： --
作者： [Toyama K, et al., 中村任]
通讯作者： 中村任
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