A daring attempt to cure glioblastoma by targeting glucose metabolism as a novel target to control glioma stem cells

糖代谢增强通常发生在人类癌症中，其对癌细胞的意义大多尚不清楚。在这个项目中，我们进行了实验，以验证葡萄糖代谢在胶质瘤干细胞维持中的关键作用这一工作假说。结果提示，抑制一种推测与葡萄糖代谢有关的细胞内分子可能会影响胶质瘤干细胞的干性，这支持了葡萄糖代谢参与胶质瘤干细胞维持的观点。

Increased glucose metabolism often occurs in human cancers, the significance of which for cancer cells remains mostly unclear. In this project, we conducted experiments to test the working hypothesis that glucose metabolism has an essential role in the maintenance of glioma stem cells. The results suggested that inhibition of an intracellular molecule presumed to be involved in glucose metabolism might affect the stemness of glioma stem cells, in support of the idea that glucose metabolism is involved in the maintenance of glioma stem cells.