Oxyfunctionalization through Photoinduced Oxygen Atom Transfer

该研究项目描述了通过光催化氧原子转移进行有机催化氧化官能化反应的进展。这种方法依赖于通过胺N-氧化物的光致裂解直接进行C-H键氧化，这将为直接引入醇功能提供一种化学工具。其具体目的是开发一种有效和可行的方法，允许直接化学合成含氧药效物质、生物活性化合物和以其他方式通过酶途径获得的外源化合物。因此，阐述一种通过胺N-氧化物的光致裂解直接进行C-H键氧化的方法不仅将解决有机合成中的一个巨大挑战，而且将同时提供与哺乳动物的芳烃和烷烃单加氧酶相同的化学等价物。

The research project delineates the development of an organocatalytic oxyfunctionalization reaction through photomediated oxygen atom transfer. Relying on the direct C‒H bond oxygenation via photomediated fragmentation of amine N-oxides, this approach will provide a chemical tool for the direct introduction of an alcohol functionality. The specific aim is to develop an efficient and practicable methodology that allows the direct chemical synthesis of oxygenated pharmacophors, biologically active compounds and xenobiotics that are otherwise accessed via enzymatic routes. Thus, elaborating a methodology for the direct C‒H bond oxygenation via photomediated fragmentation of amine N-oxides would not only address a formidable challenge in organic synthesis, it would simultaneously provide a chemical equivalent to the mammalian arene and alkane monooxygenases.