Synthesis of novel chiral anions and their application in organocatalytic reactions

ChirAnOc项目关注手性阴离子介导的有机催化过程的分子理解和进一步发展，特别是在阴离子手性离子液体（IL）的基础上。不对称偶联定向催化是近年来发展起来的一种新型的有机合成方法。阴离子手性离子液体的使用允许联合收割机将其独特的溶剂性质与有效的手性转移相结合。这些反应体系的确切机理解释将有助于优化现有的工艺，并将这种方法扩展到其他催化体系。在本项目中，研究将集中在新的手性硼酸根阴离子结构的开发。这些化合物作为助催化剂和溶剂的范围和限制将在与氮杂-Baylis-Hillman反应机械相关的选定转化中进行探索。系统的研究将提供一个更深入的了解在这些系统中的手性转移，可以有助于设计有效的有机催化转化在更广泛的基础上。从长远来看，这些基础研究将使手性离子的知识为基础的设计和应用到新的反应体系。

The project ChirAnOc is concerned with the molecular understanding and further development of chiral anion mediated organocatalytic processes, in particular on the basis of anion chiral ionic liquids (ILs). Asymmetric counterion directed catalysis (ACDC) has been introduced recently as a powerful alternative in organic synthesis. The use of anion chiral ionic liquids allows to combine their unique solvent properties with an efficient chirality transfer. An exact mechanistic explanation of these reaction systems would help to optimize existing processes and to extend this approach to other catalytic systems. In the present project the research will focus on the development of new chiral borate anion structures. The scope and limitations of these compounds as co-catalysts and solvents will be explored in selected transformations that are mechanistically related to the aza-Baylis-Hillman reaction. Systematic studies will provide a deeper understanding of the chirality transfer in these systems which can contribute to the design of efficient organocatalytic transformations on a broader basis. In the long term, these fundamental studies will enable a knowledge-based design of chiral ions and their application to new reaction systems.