Developmental studies on soft polyfluoroethylene as maxillofacial prosthesis material

1.含氟聚合物的各种性能考虑到含氟化合物的化学稳定性和拒水性或拒油性，制备了各种丙烯酸类含氟单体。将单体聚合，并测定聚合物作为假体材料的基本性质。结果表明，聚合物的溶胀使聚合物的比重增加，折射率、表面硬度和吸水率降低。此外，氟化聚合物在其表面表现出较少量的蛋白质吸附.以偏氟乙烯、三氟氯乙烯和四氟乙烯为原料，通过三元共聚制备了软质含氟聚合物。由于聚合物是可溶性的并且具有优异的机械性能，因此聚合物片材或聚合物溶液被用于制备假体材料。将甲基丙烯酸单元引入到低分子量聚氟乙烯中，发现该聚氟乙烯单体易于通过氧化还原或可见光引发剂聚合.软聚氟乙烯的应用对合成的软聚氟乙烯进行了各种生物学评价。分别进行了溶血试验或以硅橡胶为对照的细胞培养试验和大鼠皮下埋植试验。已确定聚氟乙烯不会引起任何严重的组织反应，并且聚合物在体内长期稳定。临床上应用软聚氟乙烯作为义齿软衬、组织调理剂涂层材料及各种修复体。结果表明，软聚氟乙烯是一种很有前途的颌面部修复材料。

1. Various properties of fluorinated polymer Taking into consideration the chemical stability and water- or oilrepellence of fluorinated compounds, various kinds of acrylic fluorinated monomers were prepared. The monomers were polymerized and fundamental properties of the polymers as prosthesis materials were determined. It was found that specific gravity was increased by the fluorination of polymer, and that refractive index, surface hardness and water sorption were decreased. Further, fluorinated polymer demonstrated smaller amount of protein adsorption on its surface.2. Preparation of soft polyfluoroethyleneSoft fluorinated polymer was prepared by terpolymerization of vinylidene fluoride, trifluorochloroethylene and tetrafluoroethylene. Since the polymer was soluble and possessed excellent mechanical properties, polymer sheet or polymer solution was used to prepare prosthesis materials. Methacrylic unit was incorporated into low molecular weight polyfluoroethylene and it was found that the polyfluoroethylene monomer could easily be polymerized by redox or visible light initiators.3. Application of soft polyfluoroethyleneVarious biological evaluation of the synthesized soft polyfluoroethylene were carried out. They were hemolysis test or cell culture test using silicone rubber as a control, and subcutaneous implantation test for rats. It was ascertained that the polyfluoroethylene did not cause any severe tissue reaction and that the polymer was stable in a body for a long time. The soft polyfluoroethylene was clinically applied to soft denture liner, coating material for tissue conditioner and various prostheses. Based on the results, it was concluded that the soft polyfluoroethylene was a promising material as maxillofacial prosthesis material.