Novel avenues towards double hydrophilic block copolymer-based self-assemblies

现代聚合物科学对嵌段共聚物进行了深入的研究，目的是用于生物医学应用，例如，实现高生物利用度和特异性，以减少应用剂量，并将药物准确地输送到正确的位置，以减少副作用。两亲性嵌段共聚物通常用于这方面，但其生物相容性和未来批准作为药物添加剂是有问题的。本文提出了一种解决这些问题的方法，并将聚合物药物递送剂扩展到更复杂的药物。基于生物相容性合成和生物衍生构建块的新型双亲水嵌段共聚物（DHBC）的囊泡将被研究。主要关注的是DHBC结构（如聚合物结构）与自组装性能之间的关系。此外，将对形成的聚集体的微观结构进行详细的研究，例如通过电子显微镜。为了提高形成的组件的稳定性，新的交联机制将被开发。随后，将研究聚集体在环境（水或有机）及其降解方面的稳定性。最后，基于dhbc的自组装的发展将为未来的应用提供新的机会，例如在生物医学领域。

Block copolymers are thoroughly investigated in modern polymer science aiming for biomedical applications, e.g. to achieve high bioavailability and specificity for reduction of applied doses and to deliver the drugs exactly to the right spot in order to reduce side effects. Frequently amphiphilic block copolymers are utilized in that regard, yet their biocompatibility and future approval as medicine additive are questionable. An approach to the solution of these problems and an extension of polymeric drug delivery agents towards more complex drugs is presented in this proposal. Vesicles from novel double hydrophilic block copolymers (DHBC) based on biocompatible synthetic and bio-derived building blocks will be investigated. A main concern is the relation between DHBC structures, e.g. polymer architectures, and self-assembly properties. Moreover, detailed investigations on the microstructure of the formed aggregates will be performed, e.g. via electron microscopy. To enhance stability of the formed assemblies, novel crosslinking mechanisms will be developed. Subsequently, stability of the aggregates will be studied with respect to environment (aqueous or organic) and their degradation. In the end, the development of DHBC-based self-assemblies will offer new opportunities for future applications, e.g. in the area of biomedicine.