A common and potentially prebiotic activating agent for phosphorylation of nucleosides and oligomerization of nucleotides and amino acids

氯氰诱导的RNA和多肽合成途径包括：1.核苷磷酸化为核苷酸；2.核苷酸活化为5‘-磷咪唑以进行RNA聚合；3.氨基酸活化为多肽和去保护.今年，证明了氯化氰催化氨基酸聚合在固相多肽合成中的可行性。我们还观察到，在以氯化氰为常见活化剂的一锅法合成中，核苷酸可以活化到它们的5‘-磷咪唑，用于RNA聚合和氨基酸聚合。

The proposed cyanogen chloride induced pathway for the synthesis of RNA and peptides includes: 1. phosphorylation of nucleosides to nucleotides; 2. activation of nucleotides to their 5′-phosphorimidazoles for RNA polymerization;3. activation of amino acids to peptides and deprotection. This year, the feasibility of cyanogen chloride activated polymerization of amino acids in the solid-phase peptide synthesis has been demonstrated. We also observed that activation of nucleotides to their 5′-phosphorimidazoles for RNA polymerization and amino acids polymerization can occur in a one-pot synthesis using cyanogen chloride as a common activating agent.