Organ Dysfunction in Old Age: Perspectives for Young Clinician Scientists (OrganAge)

老年器官功能障碍：年轻临床科学家的观点(器官年龄)。老年患者数量不断增加。临床医生科学家计划OrganAge的目的是为年轻医生在转化性衰老医学方面的研究生涯做好准备。科学目标：1。衰老与多个器官功能的进行性丧失有关。本方案探讨衰老机制，作为制定治疗干预措施的目标。从本质上讲，这种方法需要不同医学领域的跨学科互动。2.在OrganAge内部，我们特别希望加强转化型衰老医学--这是一个与老年病学相辅相成的领域，但在德国迄今仍不发达。结构目标：3.与OrganAge一起，我们建立了一个持久的结构，使临床医生科学家能够走上职业道路。老龄化是医学院、耶拿弗里德里希·席勒大学和莱布尼茨老龄研究所的研究重点；因此，该方案为具有不同医学背景的临床医生提供了研究机会。4.将OrganAge整合为一个从初级阶段的研究人员到成熟的研究人员的系统职业生涯路径。这条道路从获得MD的结构化计划开始，以及为高级临床医生科学家提供支持的结构(职业道路的纵向整合)。5.对项目开发的支持，以及有经验的研究人员和临床医生之间的伙伴关系，也有助于在到目前为止在老龄研究方面不太活跃的部门从事科学工作(横向扩展职业道路)，使外部科学咨询委员会能够严格根据业绩分配职位。6.我们实施了支持战略SEED-SPEED-SERVICE：SEED(例如，播种研究兴趣、早期研究人员的教育、职业规划)、SPEED(例如，受保护的研究时间、州医学会(Landesärztekammer)将研究时间确认为专家培训的时间、指导)和服务(例如，软技能培训、核心设施、融入科学网络)。7.临床医生科学家方案OrganAge被纳入其他研究项目、方案和结构，以促进老龄化研究。因此，OrganAge进一步加强了对耶拿老龄和老龄医学的国际知名度和吸引力的研究重点。支持目标：8.我们通过纳入一个具体的评估计划来分析我们计划的效果。9.我们不断改进方案结构，以增加对家庭的友好、机会平等和多样性。10.我们为知名研究人员和顶尖研究人员实施了培训方案(塑造榜样)。OrganAge将在资金结束后并入医学院。

ORGAN DYSFUNTION IN OLD AGE – PERSPECTIVES FOR YOUNG CLINICIAN SCIENTISTS (OrganAge). The number of elderly patients is continuously increasing. The aim of the Clinician Scientist Program OrganAge is to prepare young physicians for a career as researcher in translational ageing medicine. SCIENTIFIC AIMS: 1. Ageing is associated with a progressive loss of function in multiple organs. The present program explores ageing mechanisms as targets for the development of therapeutic interventions. Inherently, this approach requires interdisciplinary interactions of different medical fields. 2. Within OrganAge we specifically want to strengthen translational ageing medicine - an area complementary to geriatrics, yet hitherto underdeveloped in Germany. STRUCTURAL AIMS: 3. With OrganAge we establish an enduring structure enabling career pathways for Clinician Scientists. Ageing is a research focus of the Medical Faculty, the Friedrich Schiller University Jena and the Leibniz Institute on Aging; the program therefore offers research opportunities for clinicians with different medical backgrounds. 4. We integrated OrganAge into a systematic career pathway ranging from first stage researchers to established researchers. This pathway starts with structured programs for obtaining an MD alongside with supportive structures for Advanced Clinician Scientists (longitudinal integration of career pathways). 5. Support for project development, and partnering between experienced researchers and clinicians also enabled scientific careers in departments which have until now been less active in ageing research (horizontal extension of career pathways), allowing a strictly performance-based allocation of positions by an external Scientific Advisory Board. 6. We have implemented the support strategy SEED – SPEED - SERVICE: SEED (e.g. seeding interest in research, education of early researchers, career planning), SPEED (e.g. protected research time, recognition of research time as time for specialist training by the State Chamber of Medicine (Landesärztekammer), mentoring), and SERVICE (e.g. soft skill training, core facilities, integration into a scientific network). 7. The Clinician Scientist Program OrganAge is integrated into other research projects, programs and structures, which advance ageing research. Thus, OrganAge further strengthens the internationally visible and attractive research focus on ageing and ageing medicine in Jena. SUPPORTIVE AIMS: 8. We analyse the efficacy of our program through incorporation of a specific evaluation program. 9. We continuously improve program structures to increase family-friendliness, equal opportunity and diversity. 10. We have implemented coaching programs for established and leading researchers (shaping of role models). OrganAge will be integrated into the Medical Faculty after funding ends.