Endocrine communication of renal tubules (C03)

肾脏是重要的内分泌器官。除了特化的内分泌细胞外，肾小管细胞还释放类激素和激素，其作用于肾小管和肾小管的相邻细胞，从而影响肾功能。我们的项目旨在更好地了解肾小管激素的调节及其在健康和患病肾脏中的功能重要性。基于初步的数据，我们将集中在本地，肾小管肾素-血管紧张素系统和肾小管利钠肽。此外，新的肾小管激素，autacoids和代谢产物将被确定，并阐明其功能意义。

The kidneys are important endocrine organs. In addition to specialized endocrine cells, tubular cells also release autacoids and hormones, which act on adjacent cells of the tubules and the interstitium and thus influence kidney function. Our project aims at a better understanding of the regulation of tubular hormones and of their functional importance in the healthy and diseased kidney. Based on preliminary data, we will focus on the local, tubular renin-angiotensin system and tubular natriuretic peptides. Moreover, new tubular hormones, autacoids and metabolites will be identified and their functional significance will be clarified.