Renoprotective role of Lipocalin-2 in allograft rejection following kidney transplantation (C02)

通过肾移植小鼠模型，我们最近证明了外源性重组Lcn2：铁载体：铁复合物（rLcn2）在同种异体移植排斥反应的早期阶段具有肾保护作用。在这个项目中，我们的目标是(1)了解外源rlcn2介导的免疫调节和/或细胞保护的途径和机制；（II）表征内源性Lipocalin-2的来源和性质，即它是否与哺乳动物铁结合儿茶酚络合，并可能有助于同种异体移植物的长期存活。我们的最终目标是通过重组Lipocalin-2为移植肾保护铺平道路。

Using a mouse model of kidney transplantation, we recently demonstrated a renoprotective role of exogenously administered recombinant Lcn2:Siderophore:Fe complex (rLcn2) during the early phase of allograft rejection. In this project, we aim at (I) understanding the route and mechanisms of immunoregulation and/or cytoprotection, mediated by the exogenousrLcn2; and (II) characterizing the source and nature of endogenous Lipocalin-2 i.e. whether it is complexed with mammalian iron binding catechols and may contribute to allograft survival in the long run. Our ultimate goal is to pave the way for transplant renoprotection via recombinant Lipocalin-2.