Linking hippocampal CA3 sequences and spatial representations

海马体是大脑中与自传体情景记忆形成有关的区域。从生理学上讲，在啮齿动物的大脑中，记忆片段是由多种类型的活动序列并行的。最近，有人提出，在这些序列中，有未来新经历的预演。虽然这个想法是非常有争议的，在这个建议中，我们问这样一个想法实际上是如何机械地实现的。如果活动序列出现在空间表示之前，那么空间必须以某种方式映射到序列。在这里，我们提出了一种关于海马CA3区连接θ序列的前馈突触和spike-timing依赖性可塑性的学习机制，可以解决这一问题。该模型的预测将通过对来自合作实验室的实验数据的分析来检验。

The hippocampus is a brain area involved in the formation of autobiographic episodic memories. Physiologically, in the rodent brain, memory episodes are paralleled by multiple types of activity sequences. Recently, it it has been proposed that during some of these sequences there is preplay of future novel experiences. While this idea is highly controversial, in this proposal, we ask how would such an idea actually be mechanistically realized. If activity sequences are present prior to spatial representations, space must somehow be mapped to the sequence. Here we suggest a learning mechanism for feed forward synapses connecting theta sequences and spike-timing dependent plasticity in hippocampal area CA3 that can solve this problem. The predictions of the model will be tested by analysis of experimental data from a collaborating laboratory.