Disturbing bacterial morphogenesis by antibiotic action (A02)

抗生素酰基多肽(ADEP)通过解除对细菌CLP蛋白酶的调控，对许多革兰氏阳性病原菌具有很强的抗菌活性。杀死的方式是物种依赖的，要么是通过抑制天然的CLP功能，要么是通过激活蛋白酶来解除调节的蛋白质降解。在蛋白酶激活方面，细菌细胞分裂蛋白FtsZ是枯草芽孢杆菌和金黄色葡萄球菌的首选降解目标，这两个物种的生存都依赖于FtsZ。在产生链霉菌属中，FtsZ不是必需的，但它对通过产孢子繁殖很重要，我们在这里研究ADEP对这些细菌多细胞生命周期的影响。

Antibiotic acyldepsipeptides (ADEPs) exert potent antibacterial activity against many Gram-positive pathogens by deregulating the bacterial Clp protease. The mode of killing is species-dependent, either by inhibiting native Clp functions or by activating the protease for deregulated protein degradation. With regard to protease activation, the bacterial cell division protein FtsZ is a preferred degradation target in Bacillus subtilis and Staphylococcus aureus and both species depend on FtsZ for viability. In the producer genus Streptomyces, FtsZ is not essential, but it is important for propagation via sporulation, and we here investigate the effect of ADEP on the multicellular life cycle of these bacteria.