2022 Bacterial Cell Surfaces GRC/GRS

2022 细菌细胞表面GRC/GRS

• 批准号: 10374358
• 负责人: Michael Stephen Trent
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-14 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10374358
• 关键词: Animals; Anti-Bacterial Agents; Area; Atmosphere; Award; Bacteria; Bacterial Drug Resistance; Bacterial Physiology; Basic Science; Benign; Biochemistry; Biological Models; Biological Process; Biology; Biophysics; Career Choice; Cell division; Cell surface; Cells; Cellular biology; Climate; Columbidae; Communities; Development; Disease; Ensure; Experimental Models; Feedback; Fertilization; Fostering; Generations; Genetic; Health; Hour; Human; Image; Knowledge; Medical; Mental Health; Microbe; Mission; Modeling; Molecular; Molecular Genetics; Morphogenesis; Multi-Drug Resistance; Participant; Pathogenesis; Pharmacotherapy; Plants; Postdoctoral Fellow; Process; Research; Research Personnel; Resort; Science; Scientist; Seeds; Stress Response Signaling; Surface; Travel; United States National Institutes of Health; Vaccine Therapy; Work; antimicrobial; bacterial community; biophysical techniques; career; cell envelope; design; diversity and inclusion; educational atmosphere; gender diversity; graduate student; host-microbe interactions; improved; innovation; insight; interest; meetings; microbial community; microbiome; microbiota; microorganism; minority trainee; multi-drug resistant pathogen; new technology; novel diagnostics; novel therapeutics; novel vaccines; pathogen; pathogenic bacteria; peer; posters; programs; resistant strain; skills; structural biology; success; symposium; vaccine development

ABSTRACT This proposal seeks support for the 24th Gordon Research Conference (GRC) on Bacterial Cell Surfaces, the only meeting that connects cutting-edge research on cell envelope biology to the medically important downstream consequences of the bacterial cell surface. The 2022 meeting will be held June 26-July 1, 2022 at Mount Snow Resort, West Dover, VT and will have an associated Gordon Research Seminar (GRS). The meeting will cover topics that are of great interest to the biomedical community, especially in the current climate of the increased threat of multi-drug resistant pathogens, the need for novel vaccines, and the influence of the microbiome on human health. This GRC presents a diverse program in topics, model systems, and approaches combining biochemistry, molecular genetics, structural biology, cell biology, biophysics, imaging and modeling. There will be 9 sessions encompassing: (1) Exploring the Bacterial Cell Envelope; (2) Modifying the Bacterial Surface; (3) Cell Division and Morphogenesis; (4) Stress Responses and Signaling Across the Cell Envelope; (5) Mechanisms of Surface Recognition; (6) Transport through the Envelope; (7) Type VI and Type VII Secretion; (8) How the Surface Influences Bacterial Communities; and (9) Biophysical Methods to Improve Antimicrobial Therapies. The conference will focus on the latest, largely unpublished, and most exciting research on the assembly and function of the bacterial cell surface. We have selected a group of leading scientists, including a number of rising stars, and have closely considered seniority, gender, and diversity. To enhance the 2022 meeting, we have included roundtable discussions for junior scientists to engage with leaders of the field, the GRC Power Hour to examine issues of inclusion and diversity, and additional travel awards to support minority trainees. Additionally, we have further integrated the highly successful GRS for postdocs and graduate students with the GRC. Participants of the GRS will select 2 talks from the GRS for presentation at the GRC and the GRS co-chairs will present a summary of their meeting at the GRC opening. The traditional format of GRC meetings, with programmed discussion sessions and opportunities for informal gatherings in the afternoons and evenings, conveys a collegial atmosphere where interactions between attendees of all career stages are easily attained. The topics of this multifaceted conference are of practical interest to the biomedical community, and the mission of the NIH as it provides a platform for nucleating approaches to antibacterial strategies, vaccine development, and study of host-microbe interactions.

摘要 这项提案寻求对第24届戈登细菌细胞表面研究会议(GRC)的支持 唯一一次将细胞膜生物学的尖端研究与医学上的重要研究联系起来的会议 细菌细胞表面的下游后果。2022年会议将于2022年6月26日至7月1日在 位于佛蒙特州西多佛市的雪山度假村，并将举办相关的戈登研究研讨会(GRS)。这个 会议将讨论生物医学界非常感兴趣的话题，特别是在当前的气候下。 多重耐药病原体的威胁增加，对新疫苗的需求，以及 微生物群对人类健康的影响。该GRC在主题、模型系统和方法方面提供了不同的方案 结合生物化学、分子遗传学、结构生物学、细胞生物学、生物物理学、成像和建模。 将有9个环节，包括：(1)探索细菌细胞膜；(2)修改细菌 (3)细胞分裂和形态发生：(4)跨细胞膜的胁迫反应和信号转导； (5)表面识别机制；(6)通过包膜运输；(7)VI型和VII型分泌物； (8)表面如何影响细菌群落；及(9)改善抗菌剂的生物物理方法 治疗。会议将聚焦于最新的、基本上未发表的、最令人兴奋的关于 细菌细胞表面的组装和功能。我们选出了一批顶尖的科学家，其中包括一位 后起之秀的数量，并密切考虑了资历、性别和多样性。提升2022年 会议期间，我们还为初级科学家安排了圆桌讨论会，让他们与该领域的领导人、 GRC Power Hour研究包容性和多样性问题，以及额外的旅行奖励以支持少数族裔 实习生。此外，我们还进一步整合了针对博士后和研究生的非常成功的GRS 和GRC在一起。GRS的参与者将从GRS中选择2个演讲，在GRC和GRS上进行演讲 联席主席将在GRC开幕式上介绍他们的会议总结。GRC会议的传统形式， 通过安排下午和晚上的讨论会议和非正式聚会的机会， 传达了一种大学氛围，在这种氛围中，所有职业阶段的参与者之间的互动都很容易实现。 这次多方面会议的主题对生物医学界和代表团具有实际意义。 因为它提供了一个平台，为抗菌战略、疫苗开发、 以及研究宿主和微生物的相互作用。