DLS feedback controlled continuous particle production

来自TU布伦瑞克的微技术研究所（IMT）的可控微流体纳米颗粒发生器与美因茨的弗劳恩霍夫微工程和微系统研究所（IMM）开发的flowDLS装置的组合产生反馈控制的纳米颗粒反应器，其能够在长期稳定的过程中精确地调节颗粒的粒度、粒度分布和形状。该项目是基于IMT制药应用的芯片实验室系统的多年经验。已经在FOR“Mikropart”中，在特别控制的条件下进行的微系统中的粒子生成是一个中心议题。到目前为止，只有在单独的系统中制备后，才有可能通过测量和计数对颗粒特性进行所需的验证。flowDLS原型允许流动中的颗粒测量。在该项目中，该设备将与微流体颗粒生成单元相结合，以创建一个用户友好的系统，用于纳米颗粒生产和集成分析。设想的系统将大学一级开发的方法与弗劳恩霍夫研究所的综合分析外围相结合。它将进一步发展到工业实验室的可用性水平。应用合作伙伴ConSenxus GmbH是一家在颗粒分析方法领域拥有数十年经验的设备制造商。目标系统的特殊魅力在于其灵活性，因为整体概念包括各个模块。可以连接到系统的微流体或测量比色皿保持可互换。这意味着分析部分可以在以后与其他颗粒生产系统结合使用。ConSenxus拥有有用的联系人和必要的专业知识，可以使系统适应潜在用户的需求。该设备使用户能够以非常小的数量进入颗粒生产，无需内部分析。因此，它扩大了可能的用户群，并降低了运营商的成本和总体工作量。这是因为该设备的操作不需要经过专门培训的人员。待开发的系统可以通过泵轻松连接到主要材料供应，并在调整适当的参数后，只需按下按钮即可开始连续的颗粒生产和连续的性能监测。其目的不仅是为了满足用户的直接需求，而且还开辟了新的研究课题。例如，预计具有可控性质参数的纳米制剂的可用性，其特征在于样品中只有小的变化，这将允许对相应的生物效应进行详细研究。

The combination of a controllable microfluidic nanoparticle generator from the Institute of Microtechnology (IMT), TU Braunschweig, with the flowDLS device developed at the Fraunhofer Institute for Microengineering and Microsystems (IMM) in Mainz results in a feedback controlled nanoparticle reactor, which is capable to precisely adjust the particle size, size distribution, and shape of the particles in a long-term stable process. The project is based on many years of experince with lab-on-chip systems for pharmaceutical applications at the IMT. Already in the FOR "Mikropart", particle generation in microsystems carried out under particularly controlled conditions was a central topic. So far, the required verification of particle properties by measurement and counting is only possible after the preparation in a separate system. The flowDLS prototype allows a particle measurement in flow. Within this project, the device will be combined with a microfluidic particle generation unit to create a user-friendly system for nanoparticle production with integrated analytics. The envisaged system combines methods developed on university level with integrated analytical periphery of the Fraunhofer Institute. It will be be further developed up to the level of usability in industrial laboratories. The application partner ConSenxus GmbH is a device manufacturer with decades of experience in the field of particle analysis methods. The special charm of the targeted system is found in its flexibility, as the overall concept includes individual modules. A microfluidic or measuring cuvette that can be attached to the system remains interchangeable. This means that the analytical part can later be used in combination with further particle production systems. ConSenxus has useful contacts and the necessary special knowledge to adapt the system to the needs of potential users. The device spares users, stepping into particle production in very small quantities, the need for in-house analytics. It thus expands the possible user group and reduces costs and overall effort for the operator. This is due to the fact that no specially trained personnel is required for the operation of the device. The system to be deveoped can be easily connected to the supply of primary materials via pumps and after adjusting the appropriate parameters, continuous particle production with continuous property monitoring starts at the push of a button. The aim is not only to satisfy direct user requirements, but also to open up new research topics. For example, it is expected that the availability of nanoformulations with controllable property parameters featuring only small variances in a sample will allow detailed investigations on the respective biological effects.