Q-Band EPR-Spectrometer

所要求的光谱仪将用于(1)结构生物学，用于测量与蛋白质共价结合的氮氧化物自旋标记之间的距离，例如，阐明：热休克蛋白90反应周期中构象的变化；α-1抗胰蛋白酶的聚合机理；固有无序区域的结构，如SBH1的胞液结构域；(2)用于在体外和体内鉴定生物重要自由基的药物，包括羟化辅酶Q衍生物和利用过渡金属离子的蛋白质；(3.1)用于研究有机发光二极管和太阳能电池的发色团的光激发状态的化学；以及(3.2)用于表征芳香族硅化合物的顺磁状态的化学；(4)描述钻石色心的物理学，以协助发展脉泽和探索腔量子电动力学的新领域。

The requested spectrometer will be used in (1) structural biology for distance measurements between nitroxide spin labels covalently attached to proteins, for example to elucidate: changes in conformation during the reaction cycle of HSP90; the mechanism of polymerisation of α1 Anti-Trypsin; the structure of intrinsically disordered regions such as the cytosolic domain of Sbh1; (2) medicine for identifying biologically important radicals in cells in vitro and in vivo including hydroxylated Coenzyme Q derivatives and characterizing proteins that utilize transition metal ions; (3.1) chemistry to study photo-excited states of chromophores for organic light emitting diodes and solar cells and (3.2) to characterize paramagnetic states of aromatic silicon compounds; (4) physics for the characterisation of colour centres in diamond to assist in the development of masers and to explore new areas of cavity quantum electrodynamics.