Endogenous Appetite Modifiers of the Domestic Animals.

为了将新发现的内源性食欲调节剂应用于家畜，本文研究了内源性食欲调节剂在动物血液中的存在和变化，以及给药对动物摄食、行为和某些生理功能的影响及其作用机制。动物血浆气相色谱证实了2B40（2-丁-4-烯）的存在。该浓度在绵羊中最高，其次是牛，猪的浓度也高于鸡和大鼠。反刍动物采食后升高，禁食后降低，并维持120 h。外周给药2B40抑制绵羊进食和反刍。2B40对鸡的剂量依赖性抑制进食，即使是口服，也会引起体温过低和抑制胃运动。2B40的低体温是由于短暂的热损失加速和热产生的慢性抑制，这是用calo…More rimeter证实的。这种现象被证明是由于控制体温的设定值下降。下丘脑热损失中心微量注射2B40引起轻度高温，产热中心注射2B40引起重度低温。另一方面，使用H1， H2和5HT受体阻滞剂考察了这种低温的中枢神经化学机制。结果并没有表明低温是通过这些受体机制引起的。将大鼠相同剂量的245TP（2,4,5 -三羟基戊酸- γ -内酯）外周给予鸡时，没有明显的食物摄入加速现象。但在下丘脑外侧区微量注射245TP可促进大鼠食欲，食量增加一倍。用鸡血浆气相色谱法证实了该物质的存在。综上所述，2B40和245TP是家畜内源性食欲调节剂。少

In order to apply newly-characterized endogenous appetite modifiers to the domestic animals, their existences and variation in the blood of animals, the effects of their administration on food intake, behavior and some physiological functions, and their mechanisms were investigated.The existence of 2B40 (2-buten-4-olide) in animals was confirmed by the gaschromatogram of their plsma. The concentration was the highest in sheep, nextly in cattle, and also higher in pig than in chickens and rats. It was increased after feeding and decreased after fasting, during which the lowered level was kept for 120 hrs in ruminants.Peripheral administration of 2B40 in sheep suppressed eating and also rumination. 2B40 administration in chickens suppressed eating dose-dependently, even if orally, and it also induced hypothermia and suppressed the gastric movement.Hypothermia by 2B40 was due to trancient acceleration of heat loss and chronic inhibition of heat production, which was confirmed using a calo … More rimeter. This phenomenon was shown to be attributed to let-down of the set-point for controlling body temperature. Microinjection of 2B40 into the hypothalamic heat loss center induced a slight hyperthermia, and the injection into the heat production center induced severe hypothermia. On the other hand, the central neurochemical mechanism of this hypothermia was surveyed using the blockers to H1, H2 and 5HT receptors. Results were not obtained to in dicate that the hypothermia was induced via these receptor mechanisms.When 245TP (2, 4, 5-trihydroxy pentanoic acid gamma-lactone) of the same dose to rats was given to chickens peripherally, no clear acceleration of food intake was seen. But microinjection of 245TP into the lateral hypothalamic area accelerated appetite and their food intake was twiced. the existence of this substance was confirmed by the gaschromatogram of chicken's plasma.In conclusion, 2B40 and 245TP were confirmed to be endogenous appetite modifiers in the domestic animals. Less