Synergy between defence mechanisms and antimicrobial chemotherapy in urinary tract infections

我们研究了防御机制和抗菌化疗在尿路感染中的协同作用，以确定免疫功能低下宿主尿路感染的治疗方案。人尿中中性粒细胞的杀菌活性：尿路感染患者尿液中出现的大多数白细胞是中性粒细胞。这些中性粒细胞在低渗尿中具有最大的杀菌活性。因此，适当的饮水对治疗尿路感染是有利的。抗菌药物对白细胞杀菌活性的影响：新喹诺酮和培南在一定浓度下可增强嗜硝基粒细胞和单核细胞的杀菌活性。然而，新型喹诺酮类药物在高浓度时抑制中性粒细胞和单胞菌的杀菌活性。因此，新的喹诺酮类药物和培南类药物应用于免疫功能不全的尿路感染。免疫功能低下大鼠白细胞杀菌活性与尿路感染严重程度的关系：制备嗜中性粒细胞减少大鼠假单胞菌性肾盂肾炎模型，经环磷酰胺预处理。观察白细胞的杀菌活性与中性粒细胞减少大鼠肾盂肾炎的严重程度之间的关系。此外，粒细胞集落刺激因子（C-CSF）可以预防中性粒细胞减少大鼠的假性肾炎的严重程度。免疫功能低下宿主赖氨酸单纯性炎的预防与防治：赖氨酸单纯性炎的抑菌活性测定。对肾盂肾盂炎的严重程度有重要的预测作用。-免疫功能低下宿主的胃炎。G-CSF可以预防肾盂肾炎的严重程度。对于此类肾盂肾炎患者，应给予新的qjintones或penems，以增强白细胞的杀菌活性。

We investigated the synergy between defence mechanisms and antimicrobial chemotherapy in urinary tract infections in order to determine therapeutic fegimen for utinary tract infections in immunocompromised host.1. Bactericidal Activities of Neutrophil in Human Urine :Most leukocytes, which appear in urine from tlie patients with urinary tract infections, are neutrophils. And these neutrophits have bactericidat activities at maximum in hypotonic urine. 'Fliefefore, adequate hydration is advantageous at the treatment for urinary tract infections.2. Influence of Antimicrobial Agents on Bactericidat Activities of Leukocytes :New quinotones and penems enhance the bactericidal activities of nelitrophils and monocytes at certain concentrations. however, new quinolones suppress the bactericidal activities of neutropiiils and monocutes at high concentration. Therefore, new quinolones and penems should be administered against the urinary tract infections in imniunocompromised host.3. Relationship between Bactericidal Activities of Leuukocytes and Seriousness of Urinary Tract Infections in Immunocompromised Itats :We made the pseudomonel pyelonephritis model of neutropenic rats, which were pretreated with cyclophosphaniide. And the retationship between the bactericidal activities of leukocytes arid the seriousness of pyelonephritis in neutropenic rats was seen. Furthermore, granurocyte colony-stimulating factor (C-CSF) prevented the seriousness of psetidomonal pyf, , Ioriephritis in neutropenic rats.4. Prevention and 1'featm (, , nt for llyelonepl) ritis in Immunocompromised Host :The measurement of the bactericidal activity (, , s of I (., tikocytes is important to foresee the seriousn -ss of pyelorit. -phritis in immunocompromised host. And G-CSF prevents the seriousness of pyclonephritis. New qtjinotones or penems should be administered against pyelonephritis in such patients for enpancement of the bactericidal activities of leukocytes.