Enhancing host defence mechanisms in severe bacterial infections

增强严重细菌感染的宿主防御机制

• 批准号: nhmrc : 1142456
• 负责人: A/Pr Antje Blumenthal
• 金额: $ 56.15万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/enhancing-host-defence-bacterial-infections/1319710
• 关键词: Enhancing; host; defence; mechanisms; severe

New options to treat bacterial infections are needed because of the rapid increase in antibiotic resistance. One very attractive strategy is to boost the body’s own defence mechanisms against bacteria. This project defines novel molecular mechanisms that can be manipulated to better control a bacterial infection. Novel drugs targeting these molecular pathways are already being developed, albeit for cancer. This project will help assess if these drugs may be useful to treat infections.

由于抗生素耐药性的迅速增加，需要治疗细菌感染的新选择。一个非常有吸引力的策略是增强身体自身对细菌的防御机制。该项目定义了可以操纵以更好地控制细菌感染的新分子机制。针对这些分子通路的新药已经在开发中，尽管是针对癌症。该项目将有助于评估这些药物是否可用于治疗感染。