Effect of Essential Fatty Acid Balance on Symptoms in Various Models for Chronic Disorders.

虽然亚油酸对动物的正常生长至关重要，但α-亚麻酸对大脑和神经系统的功能很重要。饮食中α-亚麻酸和亚油酸的比例可以影响各种慢性疾病的严重性。喂富含α-亚麻酸的饮食可抑制动物模型中的实验性癌症（乳腺肿瘤、结肠癌、胰腺肿瘤、肺肿瘤、前列腺肿瘤和肾肿瘤）、过敏性疾病、血栓性疾病（心肌梗塞、脑梗塞和老年性痴呆）、高血压和脑出血。另一方面，在雌性MRL/1小鼠中，饮食对小鼠自身免疫性狼疮性肾小球肾炎没有影响。高亚油酸饮食可抑制脂多糖（LPS）联合半乳糖胺诱导的内毒素休克，而单用LPS诱导的肝炎则不受高亚油酸饮食的影响。 ...更多信息 必需脂肪酸在饮食中的比例。尽管α-亚麻酸/亚油酸的平衡对肾炎和内毒素休克的症状有复杂的影响，但有人认为亚油酸衍生的类花生酸对急性炎症性疾病的某些阶段具有保护作用。这可能是内毒素-半乳糖胺引起的必需脂肪酸依赖性毒性差异的原因之一。富含α-亚麻酸的饮食对肿瘤发生的抑制作用可能是基于TNF产生的增加。由于α-亚麻酸饮食（紫苏油）含有低水平的亚油酸酯，饲喂紫苏油饮食将影响生殖功能。然而，结果表明，在妊娠期、分娩间隔、死胎率以及胚胎和胎儿发育方面没有显着差异，表明紫苏油是安全和有用的植物油。少

While linoleic acid is essential for normal growth of animals, alpha-linolenic acid is important for the function of brain and nervous systems. The ratio between alpha-linolenate and linoleate in diets can affect the seriousness of various chronic diseases. Feeding the alpha-linolenic acid-rich diet inhibited the experimental cancer in animal models (mammary tumors, colon carcinoma, pancreatic tumors, pulmonary tumors, prostatic tumors and renal tumors), allergic disorders, thrombotic disorders (myocardial infarct, cerebral infarct and senile dementia), hypertension and cerebral hemorrhage.Dietary enrichment with linoleate relieved symptoms of anti-glomerular basement membrane nephritis. On the other hand, there was no dietary effect on murine autoimmune lupus glomerulo-nephritis in female MRL/1 mice.Endotoxin shock induced by lipopolysaccharide (LPS) combined with galactosamine was inhibited by high-linoleate diet, whereas the hepatitis induced by LPS alone was not affected by the bal … More ance of essential fatty acid in diets. Although there are complicate effects by the balance of alpha-linolenate /linoleate on symptoms of nephritis and endotoxin-shock, it was suggested that eicosanoids derived from linoleate had protective effects on some stage of acute inflammatory disorders.Macrophages from mice fed a high alpha-linolenate diet produced 10-fold more tumor necrosis factor (TNF) in response to LPS stimulation than in a high linoleate diet group. This can be one of the reason for the difference in the essential fatty acid-dependent toxicity by endotoxin-galactosamine. The suppressive effect of alpha-linolenate rich diet on tumorigenesis may be based on this increase of TNF production.Since an alpha-linolenate diet (perilla oil) contains low level of linoleate, feeding a perilla oil diet would affect the generative function. It was shown, however, that there was no significant difference in the duration of pregnancy, delivery intervals, stillbirth rates and embryonic and fetal development, indicating that perilla oil is safe and useful vegetable oil. Less