Amphiphilic nanogels based on aliphatic polycarbonates: New biodegradable nanocarriers for hydrophobic compounds

该项目将开发一种新的多功能合成平台，用于制备两亲性纳米凝胶。基于两亲性脂肪族聚碳酸酯网络，这些新的可生物降解的胶体材料将使疏水化合物的可调负载和释放成为可能。虽然传统的整体亲水性纳米凝胶递送系统仅限于亲水性货物，但这一概念将为疏水性药物的递送开辟新的治疗选择。我们的方法将能够精确调整纳米凝胶的两亲性，以不同的疏水性货物，而不影响胶体功能（大小，形状，交联）的纳米凝胶载体。因此，未来开发的载体系统将使不同纳米凝胶-药物组合的治疗效率之间具有理想的可比性。该项目结合了多个概念和方法，涉及化学，毒理学和药学方面的跨学科合作。

This project will develop a new versatile synthetic platform for the facile and scalable preparation of amphiphilic nanogels. Based on amphiphilic aliphatic polycarbonate networks, these new biodegradable colloidal materials will enable the tunable loading and release of hydrophobic compounds. While conventional overall hydrophilic nanogel delivery systems are limited to hydrophilic cargoes, this concept will open up new therapeutic options for the delivery of hydrophobic drugs. Our approach will enable precise adjustment of nanogel amphiphilicity to different hydrophobic cargoes without affecting the colloidal features (size, shape, crosslinking) of the nanogel carrier. As a result, the carrier system to be developed will, in future, enable an ideal comparability between therapeutic efficiencies of different nanogel-drug combinations. This project combines multiple concepts and methods in an interdisciplinary cooperation covering chemical, toxicological and pharmaceutical aspects.