Effect of Magnesium Deficiency on Immunoreaction

近年来，随着饮食习惯和生活方式的改变，日本的心脏病和癌症也在增加，指出良好的营养状况对预防这些疾病和保持免疫力将是非常重要的。另一方面，众所周知，镁作为几乎所有酶的激活剂起着关键作用，并且在镁缺乏时这些系统失衡，如脾脏肥大、白细胞增多、淋巴细胞异常、神经传导功能障碍，免疫反应的变化也将是预期的。脾细胞和巨噬细胞（Mphi）本研究收集了饲喂缺镁饲料和正常饲料1周或2周的大鼠。检测脾细胞有丝分裂素（ConA）、脂多糖（LPS）和细胞因子（IL-2、IL-3）的产生，以及Mphi细胞IL-1和IL-6的产生。缺镁大鼠脾细胞对ConA的反应性明显增强。缺镁大鼠脾细胞IL-2值、Mphi细胞IL-1和IL-6产生量略高。在脾T细胞与Mphi的相互作用中，缺镁大鼠Mphi对ConA的反应性较正常大鼠降低。

Recently, with the changes of food habits and life styles, heart disease and cancer in Japan are increasing, and it is pointed out that good nutritional status will be very important to prevent of these diseases and to keep immunompetence. On the other hand, it is well known that magnesium plays the key role as an activator of nealy all enzymes, and under magnesium deficiency umbalance of these systems, such as, spleen hypertrophy, leukocytosis, lymphocyte abnomality, malfunction of neurotracmission, and changes in immune responses will be also expected.Spleen cells and macrophage (Mphi) from rats fed magnesium deficient diet and normal diet for 1 or 2 weeks were collected in this study. Mitogene(ConA, LPS) and cytokines(IL-2, IL-3) productions in spleen cells, and IL-1 and IL-6 productions in Mphi were measured. Response to ConA of spleen cells of magnesium deficient rats was markedly enhanced in the compared with those of normal rats. Il-2 value in spleen cells, and IL-1 and IL-6 productions in Mphi of magnesium deficient rats were slightly higher. In interaction of T cells of spleen and Mphi, response to ConA of Mphi of magnesium deficient rats was decreased compared to normal rats.