Neurobehavioral performance of the ex-mrcury miners---20 years follow-up study

(1)为了解长期汞蒸气暴露的残留效应，对汞作业工人在汞暴露结束后18-23年进行了神经行为测试。76名男性前汞矿工谁曾接触到高浓度的汞蒸气（超过1.0毫克/立方米），并与汞中毒的历史进行了比较，对照组匹配的年龄（3年内），性别和教育。虽然汞中毒引起的症状（称为erethismus merculialis）的程度在接触结束后明显下降，但配对比较显示，接触组的运动协调、简单反应时和短时记忆的表现明显恶化。暴露变量与神经系统检查措施的多元线性回归分析显示，较差的神经系统性能和汞暴露相关的变量之间呈正相关。因此，暴露的持续时间与粪便有关。 ...更多信息 手眼协调、敲击和色卡阅读测试的RER神经学表现。按汞暴露分类的工作类别也与这些绩效呈显著负相关。接触结束后的几年时间与反应时间和数字广度的更好表现有显着相关性。另一方面，中毒史本身与当前的任何神经行为表现都没有显著相关性。这些结果表明，汞矿工在接触汞10年后仍对神经系统功能，特别是运动协调功能产生轻微但持久的影响。(2)对28名矿工进行了详细的临床神经系统检查、神经生理学测量（包括手震颤分析）、计算机姿势描记、听觉和视觉诱发电位以及神经影像学技术（如MRI和CT）的随访调查。部分中、高汞作业矿工尿B_2-微球蛋白异常。功率谱分析（傅立叶分析）揭示了一个显着的减少与功率关联的频谱形状的变化。这些变化与血浆汞水平的降低有关。部分矿工的诱发电位潜伏期明显延长，波幅降低，可能是由于宠物产时噪声过大导致听力下降所致。神经放射学检查的初步结果显示，磁共振T1或T2增强无特异性改变，仅显示部分矿工的血管梗死腔隙。然而，许多前矿工谁暴露于更高浓度的汞蒸气比其他人往往表现出萎缩的大脑皮质在X射线计算机断层扫描。少

(1) To find the residual effects of long term exposure to mercury vapor, neurobehavioral tests were given to ex-mercury miners about 18-23 years after the end of mercury exposure. Seventy sixmale ex-mercury miners who had been exposed to high concentrations of mercury vapor (over 1.0 mg/m3) and with a history of mercury intoxication were compared with controls matched for age (within 3 years), sex, and education. Although the extent of the workers'symproms caused by mercury poisoning, termed erethismus merculialis, decreased considerably after the end of exposure, matched paired comparison showed that performances of motor coordination, simple reaction time, and short term memory had deteriorated significantly in the exposed group. Multiple linear regression analysis of exposure variables with neurological examination measures showed positive correlations between poorer neurological performance and variables related to mercury exposure. Thus the duration of exposure correlated with poo … More rer neurological performance of handeye coordination, tapping, and a color card reading test. Job categories classified by the exposure to mercury also had a significant negative correlation with these performance. The period of years after the end of exposure had a signficant correlation with better performance of reaction time and digit span. On the other hand, the history of intoxication itself had no significant correlation with any of the current neurobehavioral performances. These results suggest that there are slight but persistent effects on neurobehavoral function, especially on motor coordination, among mercury miners even more than 10 years after the end of exposure.(2) Detailed clinical neurological examination, neurophysiological measurements including the analysis of hand tremor, computerized postural swsy, audio-and visual evoked potential, and neuroimaging techniques such as MRI and CT were also done as a follow-up survey of 28 these ex-miners. Some of the ex-miners who exposed moderately or highly to mercury vapor showed the abnormal value of urine B2-nicroglobulin. Power spectral analyzes (fourier analyzes) revealed a marked reduction in power association with a change in the shape of the spectra. These changes were associated with a reduction in plasma level of mercury. Some of the ex-miners showed significant delay of the latency and decreased level of the amplitudes of the evoked potential, which was probably caused by the results of the hearing loss due to the noisy pet-labor. Preliminary results of neuroradiologic findings using MRI revealed no specific changes in magmetic resonance on T1 or T2 enhancements, only showing lacuna of the vascular infarction among some of ex-miners. However, many ex-miners who exposed to higher concentrations of mercury vapor than others tended to show the atrophy of the cortical brain in X-ray computed tomography. Less