A Study on regional cerebral blood flow during contingent negative varidtion in Schizophrenics.

为研究偶发负变异（CNV）的产生机制，同时记录10例正常男性受试者的SPECT测量的CNV和区域脑流量（rCBF）。同时记录后或记录前3天，测量静息rCBF。分析12个脑电记录点CNV的早期和晚期成分。分析32个感兴趣区域（roi）的相对rCBF值和绝对rCBF值。与rCBF相比，在CNV记录期间rCBF在任何roi方面都没有显着变化。F4的早期CNV成分与右侧额叶中回和眶额皮质的r CBF显著相关。Cz和C3的晚期CNV成分与左丘脑rCBF显著相关。这些结果表明，额叶皮质和左丘脑在CNV的产生中起重要作用。

To study the generation mechanism of the contingent negative variation (CNV) , CNV and regional cerebral flow (rCBF) measured by SPECT were simultaneously recorded in 10 normal male subjects. Three days after or before the simultaneous recording, resting rCBF was measured. Both the early and late components of CNV were analyzed in 12 EEG recording sites. The relative rCBF values and absolute rCBF values were analyzed in 32 regions of interest (ROIs) . The rCBF during CNV recording showed no significant changes in any of ROIs compared with rCBF.However, the early CNV components in F4 significantly correlated with r CBF in right middle frontal gyrus and orbitofrontal cortex. And, the late CNV components in Cz and C3 significantly correlated with rCBF in the left thalamus. These results suggest that the frontal cortex and the left thalamus play an important in the generation of CNV.