Inhibition of DNA damage with the activation of gastric mucosal protection and gastric carcinogenesis

我们推测胃癌的发生可能与胃的形成机制一样，受宿主防御机制和致癌物进攻机制的平衡控制。我们测试了瑞巴派特在ENNG诱导的小鼠十二指肠癌发生中的作用。将ENNG以100 mg/L的浓度给予C57 B1/6小鼠4周。然后，小鼠给予瑞巴派特（20或50mg/kg）16周。实验第16周处死小鼠，切除十二指肠和胃。通过体视显微镜检查十二指肠肿瘤，并记录其发生率和大小。ENNG组、ENNG +20mg/kg瑞巴派特组和ENNG +50mg/kg瑞巴派特组的十二指肠肿瘤发生率分别为66.7%、58.1%和45.2%。ENNG组与ENNG+瑞巴派特组比较差异无显著性。给予瑞巴派特。实验第48周，肉眼检查腺胃有无肿瘤，并记录组织学检查结果。MNNG组和MNNG+瑞巴派特20mg/kg组胃癌发生率分别为76.9%和61.5%。两组之间的发生率无显著差异。在胃肿瘤组织学研究中，MNNG和MNNG+瑞巴派特治疗组的癌和腺瘤发生率分别为69.2%和30.7%。两组间差异有显著性（P <0.05）。

We hypothesized that gastric carcinogenesis may controlled by the balance of the host defense mechanism and offense by carcinogen like a mechansisms of gastric formation. We tested Rebamipide in ENNG-induced mouse duodenal carcinogenesis. ENNG was administered to the C57B1/6 mice at a concentration of 100 mg/L for 4 weeks. Then, the mice were given Rebamipide (20 or 50mg/kg) for 16 weeks. In the 16th week of the experiment, the mice were killed and the duodenum and stomach were resected. Duodenal tumors were examined by stereomicroscopy, and their incidence and size were recorded. The incidence of duodenal tumors in mice treated with ENNG,ENNG plus 20mg/kg Rebamipide and ENNG plus 50mg/kg Rebamipide was 66.7%, 58.1% and 45.2% respectively. The difference between the group treated with ENNG and the group treated with ENNG plus Rebamipide was not significant.Male wistar rats were given MNNG at a concentration of 80 mg/L for 28 weeks. Rebamipide was administered. In the 48th week of the expriment, the glandular stomach was examined for macroscopic tumors and histological examination were recorded. The incidence of gastric carcinogenesis in the group treated with MNNG and MNNG plus 20mg/kg Rebamipide was 76.9% and 61.5%, respectively. The incidence between the both groups were not significantly different. In the histological study of gastric tumors, the incidence of carcinoma and adenoma in the MNNG and MNNG Plus Rebamipide treated group were 69.2% and 30.7% respectively. The defference between these groups were significant (p<0.05).