The effects of oral potassium and magnesium supplementation on blood pressure and the serum lipid level in humans

本研究旨在探讨口服镁（Mg）对血压（BP）及相关因素如尿儿茶酚胺和脂质代谢的影响。在第一项研究（13例健康年轻受试者）中，进行了一项双盲、交叉研究（研究-I），而第二项研究包括30例老年受试者（研究-II）。在研究I中，受试者分别食用对照饮食（Ca：500，Mg 250 mg/天）并口服补充安慰剂（P期）和口服补充氢氧化镁（Mg：393- 471 mg/天）并食用对照饮食（Mg期）10天。尿镁排泄量显着增加在镁期间，而收缩压和舒张压之间的P和镁期间没有变化。与P期相比，Mg期的尿去甲肾上腺素排泄（UNE）降低了12%，而其他相关变量在Mg补充期间没有变化。此外，在Mg-期间，UNE和BP签署 ...更多信息 24小时尿镁排泄量增加到P期的2倍的受试者，其尿镁排泄量明显降低。在Mg-期间，LCAT也显著增加，但HDL-胆固醇、总胆固醇和甘油三酯均保持不变。在研究II中，收缩压和舒张压在Mg期显著降低，但在P期没有。血浆醛固酮浓度和红细胞压积显着增加镁时期相比，控制期。补充镁后，尿钾排泄量与尿钾排泄量呈显著正相关，LCAT、HDL-胆固醇和apo-AI显著升高。因此，这些结果表明，镁补充剂可以通过尿钠排泄和抑制UNE释放来降低血压，并通过激活LCAT来改善人类的脂质水平。少

The aim of this study is to examine the effects of oral magnesium (Mg) supplementation on blood pressure (BP) and related factors, such as urinary catecholamine, and the lipid metabolism. In the first study (13 healthy young subjects), a double-blind, crossover study was performed (Study-I) while the second study consisted of 30 elderly subjects (Study-II). In study I, the subjects consumed a control-diet (Ca : 500, Mg 250mg/day) with oral supplementation of a placebo (P-period), and the oral supplementation of Mg-hydroxide (Mg : 393-471mg/day) with the control diet (Mg-period) for 10 days, respectively. The urinary Mg excretion significantly increased during the Mg-period, while the systolic and diastolic BP did not change between the p- and Mg-periods. The urinary norepinephrine excretion (UNE) decreased 12% during the Mg-period compared to the P-period, whereas the other related variables did not change during Mg supplementation. In addition, the UNE and BP during the Mg-period sign … More ificantly decreased in the subjects whose 24-hurinary Mg excretion increased to twice that in the P-period. The LCAT also significantly increased during the Mg-period, but the HDL-cholesterol, total-cholesterol and triglyceride all remained unchanged. In studyII, the systolic and diastolic BP significantly decreased during the Mg-period, but not in the P-period. The plasma aldosterone concentration and hematocrit significantly increased in the Mg-period compared to the control period. There was also a significant positive correlation between the %-change from the control to the Mg-period of the UNE and that of the diastolic BP.However, the urinary K excretion positively correlated with the UNE.A statistically significant increase in the LCAT, HDL-cholesterol and apo-AI was observed after Mg supplementation. These results therefore suggest that Mg supplementation may both lower the BP through natriuresis and the suppression of UNE release, and improve the lipid levels through the activatation of LCAT in humans. Less