Formation od lipid membranes in organic solutions and their functionalization

本研究以L-谷氨酸为原料，合成了含一个芳香头基团和两个长链烷基团的特殊脂类，并研究了它们在有机溶液中的聚集行为。研究结果如下：1)在苯溶液中，只有头基和烷基通过酰胺键引入的脂类才能形成高度定向的结构。计算机计算表明，每个分子的3个酰胺键提供了脂类之间有效的分子间氢键。2)合成了以山梨基为头基的脂类。这种脂质在乙醇中产生了高度定向的结构。3)用这些高度定向的聚集体考察了氨基酸衍生物在苯溶液中的选择性洗脱行为。当含有吡啶头基团的脂质混合在聚集体中时，观察到有效的对映选择性。DSC和CD研究表明，选择性是通过含吡啶类脂的相分离来实现的。

In this study, special lipids having an aromatic head group and two long-chain alkyl group have been synthesized from L-glutamic acid and their aggregation behavior in organic solutions has been investigated. The results can be summarized as follows :1) Only the lipids into which the head and alkyl groups were introduced through amide binding can form highly-oriented structures in benzene solutions. The computer calculation indicated that the three amide bonding per molecule provide effective intermolecular hydrogen bonding among lipids.2) The lipid with a sorbyl group as a head group was synthesized. This lipid produced highly-oriented structure in ethanol. The uv-irradiation induced intermolecular condensation between sorbyl groups.3) The selective elution behavior of amino acid-derivatives was also examined using these highly-oriented aggregates in benzene solutions. When the lipid with a pyridinium-head group was mixed in the aggregates, effective enantioselectivity was observed. DSC and CD studies indicate that the selectivity is performed through the phase separation of pyridinium-containing lipids.