Experimental study on endovascular therapy for aortic dissection

我们利用犬主动脉夹层模型研究了一种新的主动脉夹层腔内治疗装置。1)主动脉夹层模型：我们用人工血管移植物在狗的降主动脉上建立了搭桥通道。我们在手术后2周和4周评估旁路通道的通畅性为假腔。2)该装置是为直接关闭主动脉夹层入口而设计和制造的。它由一个气球和一个补丁组成。使用凝固液(HEMA)可以使球囊永久保持其膨胀的形状。3)实验：我们在主动脉夹层模型上测试了我们的装置。不可能通过导管插入装置，所以我们通过主动脉切开将装置放置在降主动脉。2周后行血管造影评估，关闭旁路通道。这表明了我们的设备的有效性。然而，1个月后球囊破裂，旁路通道获得专利。4)结论：我们的目标是开发一种新的主动脉夹层腔内治疗装置。通过实验表明了我们的新装置的有效性。需要进一步改进该装置和建立主动脉夹层的动物模型。

We investigated a new device of endovascular therapy for aortic dissection using a canine aortic dissection model.1) Aortic dissection model : We created bypass channel in the descendingaorta of a mongrel dogusing a prosthetic tube graft. We evaluated patency of bypass channel as false lumen 2 and 4 weeks after the procedure.2) Device ; The device was designed and made to close directly the entry of aortic dissection. It consists a balloon and a patch. The balloon can permanently maintain its inflated shape with solidifying liquids (HEMA).3) Experiment ; We testedour device in aortic dissection model. It was impossible to insert the device through catheter, so we place the device through the aortotomy in the descending aorta. On angiographic evaluation 2 weeks later, bypass channel was closed. It suggested the efficacy of our device. However, balloon was broken one month later and bypasses channel was patent.4) Conclusion ; We aimed to develop a new device for endovascular therapy of aortic dissection. The efficacy of our new device was suggested through the experiment. Further improvement of the device and an animal model of aortic dissection were needed.