Breaking selective constraints: is Hsp90 a capacitor of evolutionary change?

基因的作用和表达可以通过遗传机制进行调节。如果存在一种易于操纵的控制基因表达的一般机制，就有可能使动植物育种者能够快速产生和选择具有农业重要性的新性状，而不需要依赖转基因和长期育种计划。它还将帮助开发工具，以识别和检测增加人类疾病易感性的基因，如癌症，这些疾病只有在某些环境条件下才能表达。我打算确定Hsp90蛋白是否代表了一种控制基因表达的一般机制。

Gene action and expression can be modulated by genetic mechanisms. If a general mechanism controlling gene expression exists that can be easily manipulated it has the potential to allow animal and plant breeders to quickly produce and select for new characters of agricultural importance without relying on transgenics and long-term breeding programs. It would also assist in the development of tools for identifying and detecting genes that increase susceptibility to human diseases, such as cancer, that are only expressed under certain conditions environmental. I intend to determine whether the protein Hsp90 represents a general mechanism controlling gene expression.