Radioallergo sorbent Test For Specific Ig E Antibody To Lidocaine, Procaine. and Methylparaben.

虽然对局麻药的类过敏反应是众所周知的，但用于检测特异性药物反应原（IgE）抗体的放射性过敏吸收试验（RAST）尚未被开发出来。我们采用利多卡因、普鲁卡因和对羟基苯甲酸甲酯的羧酸衍生物建立了局麻药的快速反应区。血清样本取自100名志愿者，他们对所使用的药物没有过敏反应。这些志愿者的RAST阴性值分别为：利多卡因1653 254 (SD) cpm、普鲁卡因2750 264cpm、对羟基苯甲酸甲酯2805 336cpm。

Although anaphylactoid reactions to local anesthetics are well known, a radio allergosorbent test (RAST) to detect specific drug reagin (IgE) anti-body has not been developed. We established RAST for local anesthetics by using carboxylic acids derivatives of lidocaine, procaine and methylparaben. Serum samples were taken from 100 volunteers who had no allergies to the drugs used. Negative RAST values obtained from these volunteers were 1653 254 (SD) cpm(lidocaine), 2750 264cpm (procaine), and 2805 336cpm(msthylparaben).