Studies on the mechanism of thrombosis formation in hypoalbuminemia and hyperlipidemia.

近年来血栓性疾病呈上升趋势。在各种疾病状态中，已知血栓性发作经常与肾病综合征相关，肾病综合征的特征是高脂血症和低白蛋白血症。然而，在这种综合征中血栓形成的机制仍有待阐明。为了阐明低白蛋白血症和高脂血症下血栓形成的机制，在长濑无白蛋白血症大鼠（NAR）中表征凝血和纤溶状态，其揭示了类似于肾病综合征的病理学条件;即无白蛋白血症和高脂血症。在nar和Sprague-Dawrey大鼠（SDR）血浆中发现抗人凝血因子Xa（FXa）活性，nar大鼠的FXa活性比SDR大鼠高2-3倍。虽然负责抗人F-Xa活性的血浆成分尚未完全确定，但α 2-巨球蛋白可能是良好的候选者之一。血浆抗凝血酶III（AT III）水平和 ...更多信息 d α 2-纤溶酶抑制剂在NAR组高于SDR组.当对NAR和SDR给予内毒素时，NAR的死亡率显著高于SDR（分别为30%和0%）。通过对上述实验性DIC动物凝血和纤溶指标的观察发现，NAR比SDR更易诱发DIC.当通过插入微玻璃移液管在大鼠的小肠系膜动脉中诱导血栓时，在两只动物中，血栓在插入后4-5分钟内形成。由此形成的血栓逐渐变大，从玻璃管和血管壁分离并飞到循环中。SDR在血栓形成后3-4 min内血栓即消失，而NAR在血栓形成后12-15 min内血栓即消失，其最大血栓体积是SDR的3倍。低白蛋白血症和高脂血症本身可能是血栓形成的危险因素。少

Thrombotic diseases are increasing recently. Among the various dsisease states, thrombotic episodes have been known to associate frequently with nephrotic syndrome which is characterized by hyperlipidemia and hypoalbuminemia. However, mechanism by which thrombus can be formed in this syndrome remains to be clarified. To elucidate the mechanism of thrombus formation under hypoalbuminemia and hyperlipidemia, coagulation and fibrinolytic states were characterized in Nagase analbuminemia rats (NAR) which reveals the patological condtions similar to nephrotic syndrome; i.e.analubuminemia and hyperlipidemia.1. Anti human facotor Xa (FXa) activity was found in plasma of nar and Sprague-Dawrey rats (SDR), the value of which was found to be 2-3 times higher in nar than that in SDR. Although the plasma component responsible for the anti human F-Xa activity has not yet been fully identified, alpha2-macroglobulin may be possibly one of good candidates. Plasma levels of antithrombin III (at III) an … More d alpha2-plasmin inhibitor were higher in NAR than those in SDR.2. When endotoxin was administered to NAR and SDR, mortality was significantly higher in NAR than that in SDR (30 % vs 0 %, respectively). Based on the findings of the changes in coagulation and fibrinolysis of these experimental DIC animals, severer DIC was induced in NAR than in SDR.3. When thrombus was induced in the small mesenteric artery of rats by inserting the microglass pipette, thrombus was formed within 4-5 min of insertion in both animals. Thrombus thus formed gradually grew up in its size to dissociate from the glasspipette and vascular wall and flew away into circulation. Thrombus was disappeared in such a way within 3-4 min of the thrombus formation in SDR, whereas thrombus was disappeared at 12-15 min of the formation in NAR and the maximum size of thrombus was 3 times bigger in NAR than that in SDR.These findings suggested that NAR might be sensitive to the stimuli causing to the thrombus formation and , thus, hypoalbuminemia and hyperlipidemia per se might be the risk factors for the thrombus formation. Less