Roles of Vartous Natriuretic Factors in Essential Hypertensives

本实验以自发性高血压大鼠（SHR）、Dahl盐敏感（D-S）或盐抵抗（D-R）大鼠及原发性高血压大鼠为模型，研究了各种利钠因子在高血压发病中的作用。在体内肾灌注实验中，认为SHR的利钠作用主要依赖于肾素-血管紧张素（R-A）系统的活性，因为通过施用血管紧张素转换酶（ACE）抑制剂MK 422（依那普利拉）改善了对盐输注的紊乱的利钠反应。在D-s大鼠中，MK 422未改善促钠反应。由于吲哚美辛可加重D-R大鼠的利钠反应，其程度与D-S大鼠相似，推测D-S大鼠体内前列腺素（PGE_2、PGF_2）的分泌紊乱可能起重要作用。 ...更多信息 交感神经活性、R-A系统活性和各种利钠因子如多巴胺、激肽释放酶系统、肾上腺素、心房利钠肽（ANP）和Na，K-ATP酶抑制剂。在正常或高血压患者中，交感神经活动和R-A系统在控制尿钠排泄中起重要作用。在部分低肾素患者中，表现为尿钠排泄紊乱，肾脏中的多巴胺和激肽释放酶-激肽系统似乎对正常钠尿排泄患者和钠尿排泄紊乱患者之间的ANP起重要作用。部分低肾素原发性低血压患者尿Na，K-ATP酶抑制剂排泄增加，提示原发性高血压和遗传性高血压大鼠尿钠排泄紊乱，尿钠排泄紊乱可能与高血压的发生发展有关。在每种患者和大鼠种属中，钠尿排泄障碍的原因各不相同。少

The roles of various natriuretic factors in the pathogenesis of hypertension was studied in genetically hypertensive rats such as spontaneously hypertensive rats (SHR) and Dahl salt sensitive (D-S) or salt resistant (D-R) rats and in essential hypertensives, In the experiments using an in vivo renal perfusion system, it was considered that natriuresis was mainly dependent on activity of the renin-angiotensin (R-A) system in SHR, since disturbed natriuretic response to salt infusion was improved by the administration of an angiotensin converting enzyme (ACE) inhibitor, MK422 (enalaprilat). In D-s rats natriuetic response was not improved by MK422. As natriuretic response in D-R rats aggravated by the administration of indomethacin to the extent similar to that D-S tats, it was supposed that disturbed production of prostaglandins such as PGE_2 and PGF_2 may play an important role in D-S rats.In essential hyportensives natriuretic response to acute salt loading seemed to be controlled by … More the sympathetic nerve activity, activity of the R-A system and various natriuretic factors such as dopamine, kallikrein system, prostaglandins, atrial natriuretic poptide (ANP) and Na,K-ATPase inhibitors. In patients with nomal or high renin the sympathetic nerve activity and the R-A system seemed to play an important role in the control of natriuresis. In some patients with low renin who showed disturbed natriuresis, dopamine and the kallikrein-kinin system in the kidney seemed to be important for the ANP between patients with normal natriuesis and those with disturbed natriuesis. In some patients with low renin essential hyportensives, urinary excretion of Na, K-ATPase inhibitors was increased.From these studies it was concluded that urinary excretion of sodium is disturbed in essential hypertensives and in genetically hypertensives rats and its disturbance may be related to the development of hypertension. The causes of the disturbance in urinary excretion of sodium are various in each patient and rat species. Less