Effet of CNS on ODC activity in rat intestine

本研究的目的是评估大鼠小肠粘膜中鸟氨酸脱羧酶(ODC)的活性在一定程度上受中枢神经系统的控制。在第一个实验中，我们证明了切断迷走神经干对禁食大鼠肠黏膜中ODC活性的影响。迷走神经干切断术可消除暗周期前十二指肠ODC活性的升高。在第二个实验中，显示了2-脱氧-D-葡萄糖诱导的中枢神经系统的糖基化效应。向第三脑室注入2-脱氧-D-葡萄糖可剂量依赖性地激活肠粘膜中的ODC。这种增加被迷走神经干切断术减弱。结果表明，中枢神经系统除与局部因素有关外，还与大鼠肠黏膜ODC活性升高有关。

The aim of the present study was to evaluate that ornithine decarboxylase (ODC) activity in the rat small intestinal mucosa is controlled, in part, by the central nervous system. In the first experiment, we demonstrated an effect of truncal vagotomy on ODC activity in the intestinal mucosa of fasted rats. The increase of ODC activity in the duodenum just before the dark period was abolished by truncal vagotomy. In the second experiment, an effect of glycoprivation of the central nervous system induced by 2-deoxy-D-glucose was shown. Infusion of 2-deoxy-D-glucose into the third cerebroventricle activated ODC in the intestinal mucosa in a dose-dependent manner. This increase was attenuated by truncal vagotomy. The results indicate that the central nervous system, in addition to local factors, is related to the increase of ODC activity in the rat intestinal mucosa.