Chemical shift imaging of prostatic cancer using a intra-cavity coil

本研究的目的是评价1H-MR波谱检查（MRS），尤其是化学位移成像（CIS）在前列腺癌患者中的应用价值。首先，在健康志愿者中进行2D-CIS，使用体线圈作为发射线圈，直肠内表面线圈作为接收线圈。我们可以检测到柠檬酸峰，这是已知的丰富的物质在正常前列腺和前列腺癌较少。但是柠檬酸盐的信号非常弱，我们无法显示每个体素中的柠檬酸盐量。我们未能成功的原因是由于脂肪和水的抑制不完全和直肠内接收线圈的灵敏度较低，信噪比差，现在我们试图改进接收线圈和脂肪和水的抑制方法。然后我们将进行下一步，即在前列腺癌患者中进行临床评估。

The purpose of our study was to evaluate the usefulness of 1H-MR specroscopy (MRS), especially chemical shift imaging (CIS), in the patients with prostatic cancer.We used 1.5 T super conductive MR unit in this study. Initially, 2D-CIS was performed in healthy volunteer, using body coil as transmission coil and endorectal surface coil as receiver coil. We could detect the citrate peak, which is known as the rich substance in normal prostate gland and less in prostate cancer. But the signal from citrate was so weak, that we could not show amount of citrate in each voxel. The reason why we could not success was poor signal to noise ratio due to incomplete fat- and water-suppression and lower sensitivity of endorectal receiver coil.Now we try to improve the receiver coil and fat- and water-suppression method. Then we will go next step, that is to say, clinical evaluation in the patient with prostatic cancer.