THE METABOLISM AND CLINICAL IMPLICATION OF ADENOSINE IN HUMAN FETAL BLOOD

腺苷在人类胚胎中的生理作用和代谢还没有得到很好的研究。本研究通过测定IUGR、先兆子痫等不同病理物理条件下胎儿血浆腺苷浓度，探讨血浆腺苷浓度与胎儿PO_2、PCO_2、pH、呼吸运动、胎盘循环的关系。IUGR受精者血浆腺苷浓度显著升高，且与胎儿PO_2、PH呈负相关。此外，在腹股沟-胎盘缺血期间，胎儿-胎盘循环中腺苷的产生增加。我们的结果表明，腺苷可能在人类胎儿的许多生理状态中发挥重要作用。然而，腺苷在人类胚胎中的生理作用还不是很清楚。应该需要进一步的调查。

The physlologlcal roles and metabolism of adenosine in the human fetuses has not been well investigated. In this research, we measured fetal plasma adenosine concentration in various pathophysical conditions in complicatedd pregnaneies, such as IUGR and preeclampsia.We then evaluated the relationship between plasmaadenosine concentration and fetal PO_2, pCO_2, pH,breathing movements, fetoplacental circulation.Plasma adenosine concentration was elevated significantly in IUGR feruses, and which inversely correlated with fetal PO_2 and pH.An elevation of plasma adenosine concentration was related to the decrease of fetal breathing movements. Moreover, the production of adenosine in fetoplacental circulation was enhanced duringuteroplacental ischemia.Our results suggests that adenosine may play an important role in many path physiological conditions in human fetuses. However, the physiological roles of adenosine in the human fetuses has not been well understood. Further investigation should be needed.