Regression effect Experimental Ocular Neovascularization with Systemic Interferon-beta

系统性干扰素- β对实验性眼部新生血管的消退作用Hirohiko Miki, Motomaro Nakajima（关西医科大学）[目的]眼内新生血管形成导致许多眼病的视力丧失，包括角膜新生血管形成、新生血管性青光眼、糖尿病视网膜病变和老年性黄斑变性。目前的治疗依赖于激光光凝，涉及到眼功能组织的破坏。针对新生血管的一种新的药理学治疗将是一项重大进展。[方法]研究人干扰素- β对兔双眼长睫状动脉闭塞致眼前段缺血后角膜和虹膜新生血管的影响。干扰素- β被系统地给予有血管造影记录的新生血管的动物。术后第10天和第15天进行组织病理学检查和准备。[结果]治疗组兔眼血管造影和组织学表现出新生血管的消退，尤其是虹膜新生血管的消退。记录有角膜和虹膜新生血管形成的对照眼，在没有药物治疗的情况下，所有眼睛的新生血管都有进展。[结论]在角膜和虹膜新生血管实验模型中，全身性干扰素- β有抑制新生血管形成和新生血管消退的作用。虹膜新生血管的消退作用大于角膜新生血管的消退。干扰素可作为治疗眼部新生血管疾病的有效药物。

"Regression effect of Experimental Ocular Neovascularization with Systemic Interferon-beta."Hirohiko Miki, Motomaro Nakajima(Kansai Medical University)[Purpose]Intraocular neovascularization leads to visual loss in many eye diseases, including corneal neovascularization, neovascular glaucoma, diabetic retinopathy and age-related macular degeneration. Current treatment relies on laser photocoagulation, involving the destruction of functional ocular tissues. A new phamacologic treatment directed at the newly growing vessels would represent a major advance.[Method]We studied the effect of human interferon-beta in an experimental model of corneal and iris neovascularization after ocular anterior segment ischemia produced by occlusion of both long ciliary arteries in rabbits eyes.Interferon-beta was administrated systemically to animals with angiographically documented neovascularization. Histopathological examination was also investigated with preparation after encleation on 10 and 15th day postoperatively.[Results]Rabbits eyes in the treatment group showed regression of neovascularization angiographically and histologically, especially in iris neovascularization. Control eyes with documented corneal and iris neovascularization, followed without drug treatment, showed progression of neovascularization in all eyes.[Conclusion]Systemic interferon-beta let to inhibition of neovascularization and regression of new vessels in an experimental model of corneal and iris neovascularization. It's effect of regression was more in iris neovascularization than in cornea. Interferon-beta may be effective as a medication for the treatment of the ocular neovascular diseases.