Disentangling pharmacologic and expectation effects in antidepressant discontinuation - a randomized, balanced open-hidden trial (A15)

A15项目将把研究抗抑郁药物治疗中安慰剂和反安慰剂效应所获得的知识转移到停药领域。基于对停药的功能失调预期会导致痛苦症状的发生，并增加停药后复发的风险，本项目将对服用SSRIs/SNRIs的患者进行随机、平衡的开放隐藏停药试验。因素、治疗和期望将有所不同，以系统地评估它们各自对停药症状发展的贡献。

Project A15 will transfer the knowledge gained in researching placebo and nocebo effects in antidepressant treatments to the field of medication discontinuation. Building on the observation that dysfunctional expectation about discontinuation contributes to the occurrence of distressing symptoms and raises the risk of relapse after stopping antidepressant treatments, this project will conduct a randomized, balanced open-hidden discontinuation trial with patients taking SSRIs/SNRIs. The factors treatment and expectation will be varied to systematically assess their respective contribution to the development of discontinuation symptoms.