Transcriptional Mechanisms of Atrial Remodelling and Arrhythmia (P03)

本项目研究房颤（AF）期间心房重构和心律失常发生的分子和细胞机制，房颤是人类最常见的心律失常类型。结构和电生理重构是房颤的基本特征，与心房心肌异细胞性质的显著和动态变化有关。P03将在体外和体内探索由转录因子ETV1介导的心房细胞类型特异性基因调控，并预测在小鼠模型中发现的与猪和人房颤遗传学和病理生理学的联系。

This project investigates molecular and cellular mechanisms of atrial remodelling and arrhyth-mogenesis during atrial fibrillation (AF), the most prevalent type of arrhythmia in humans. Structural and electro¬physiological remodelling are essential hallmarks of AF, associated with pronounced and dynamic changes in the heterocellular nature of atrial myocardium. P03 will explore atrial cell type-specific gene regulation, mediated by the transcription factor ETV1, in vitro and in vivo, and project the links identified in murine models to genetics and pathophysiology of pig and human AF.