Visible light mediated photochemical metal-free carbene transfer reactions

在这个研究项目中，我们计划系统地研究光化学的、无金属的卡宾转移反应，以开发新的、可持续的合成方法，并进一步加深对卡宾中间体在有机合成中的反应性的理解。为了实现这一目标，我们将利用可见光光解来研究有机合成方法中的有色给体-受体重氮烷。研究活动的重点是通过光化学生成的卡宾形成游离叶立德中间体。研究了这些叶立德在S型重排、环化和扩环反应中的作用。在最后一部分中，我们将研究多卡宾与带有几个亲核基团的底物的转移反应，从而为低聚环丙烷和稠合四氢呋喃的合成开辟了新的途径。

In this research project, we plan to systematically investigate photochemical, metal-free carbene transfer reactions in order to develop new and sustainable synthetic methods and to further deepen the understanding of the reactivity of carbene intermediates in organic synthesis. To achieve this goal, we will use the visible light photolysis to investigate colored donor-acceptor diazoalkanes in organic synthesis methodology. Research activities focus on the formation of free ylide intermediates via photochemically generated carbenes. These ylides are studied in sigmatropic rearrangement, cyclization, and ring expansion reactions. In the last part, we will investigate multi-carbene transfer reactions with substrates that carry several nucleophilic groups, thus opening up ways for the synthesis of oligo-cyclopropa(e)nes and fused tetrahydrofurans.