Single cell approaches to define cellular programming by environmental stimuli (P02)

免疫系统对环境中存在的许多物质以及生活方式因素(如缺乏锻炼或西式饮食)做出反应，这些因素可能会引发免疫反应不足，导致慢性低度炎症。利用单细胞组学(SCO)技术，我们的目标是通过开发一种基于全血的化合物孵育试验来识别诱导元融合的化合物-典型地测试AhR配体-并将该试验转化为临床环境，以评估个体对环境元融合驱动化合物的反应性，从而了解元融合过程中的(细胞间)和分子的复杂性。

The immune system responds to many substances present in our environment as well as lifestyle factors such as lack of exercise or Western-type diets, that can trigger inadequate immune reactions leading to chronic low-grade inflammation. Using single cell omics (SCO) technologies, we aim to understand the (inter)cellular and molecular complexity during metaflammation by developing a whole blood-based compound incubation assay to identify compounds that induce metaflammation - prototypically tested for AhR ligands-, and by translating this assay into a clinical setting to assess individual reactivities to environmental metaflammation-driving compounds.