New models for the role of chromatin in controlling inducible gene expression

这个提议的目的是测试如何包装DNA在细胞核中发挥基因表达的基本作用的新模型。理解这些概念对于成功的基因治疗是非常重要的，因为基因治疗需要克服主要的障碍。这项工作对体细胞治疗也有影响，因为了解基因如何表达以成功地重编程细胞是很重要的。这两个领域对生物技术产业都很重要。回答有关基因转录中高阶染色质结构的问题将提供具有国际意义的前沿创新知识。

This proposal aims to test novel models of how packaging of DNA in the nucleus plays a fundamental role in gene expression. Understanding these concepts is important in the context of successful gene therapy where major hurdles need to be overcome. This work also has implications for somatic cell therapy since it is important to understand how genes are expressed in order to successfully reprogram cells. Both of these areas are important to the Biotechnology industry. Answering questions about higher order chromatin structure in gene transcription will provide cutting edge, innovative knowledge that will have international significance.