Epidemiological studies of the relationships between periodontal diseases and systemic health

这项研究的目的是检验牙周病和全身健康之间的偶然和流行病学关系。我们从七个不同的试验组获得了如下结论1.(宫崎骏H)我们分析了78岁的日本社区老年人的血清维生素C、钙和白蛋白浓度与牙周疾病进展的关系。结果表明，维生素C、钙和白蛋白水平降低独立影响老年人牙周破坏的进展。2.(武原T和安塞T)我们分析了进食率与脂肪细胞衍生激素、脂联素和瘦素的关系。提示，良好的咀嚼和缓慢的进食可能会导致代谢综合征的预防策略。3.(Nakagaki H)本研究旨在探讨牙周炎患者吸烟习惯与血液检测值之间的关系。这项研究的结果有助于澄清…CRP值与牙周病的相关性更强，提示其有可能作为牙周病的筛查指标。4.(Yamashita Y和Saito T)日本女性牙周病与代谢综合征密切相关。在几种脂肪细胞因子中，抵抗素在牙周病患者中被认为是升高的。5.牙龈假单胞菌感染与低密度脂蛋白-胆固醇升高有关。6.(Watanabe T、Yamamoto T和Tomofuji T)局部应用脂多糖和蛋白水解酶建立实验性大鼠牙周炎模型。在大鼠牙周炎模型中，发现了脑、心、肝、肾的氧化损伤。7.以霍乱毒素为粘膜佐剂，核盘藻外膜蛋白与唾液他汀肽结合，可诱导小鼠的粘膜和全身免疫反应。较少

The purpose of this research project was to examine the casual and epidemiological relationships between periodontal diseases and systemic health. We obtained conclusions described below from seven different experimental groups.1.(Miyazaki H) We analyzed the relationship between periodontal disease progression and serum vitamin C, calcium and albumin concentrations obtained from community-dwelling elderly Japanese aged 78 years. The results suggest that lower vitamin C, calcium and albumin levels independently influence to progress periodontal destruction in elderly people.2.(Takehara T and Ansai T) We analyzed an association between the rate of eating and adipocyte-derived hormones, adiponectin and leptin. It was suggested that chewing well and eating slow may lead to a preventive strategy for metabolic syndrome.3.(Nakagaki H) This study was undertaken the relation between smoking habits and blood test values of persons with periodontitis. The results of this study helped clarify the … More relationship between the CRP value and periodontal disease, suggesting the possibility that this can be used as a screening test for periodontal disease.4.(Yamashita Y and Saito T) Periodontal disease was closely associated with metabolic syndrome in Japanese women. Within several kinds of adipocytokines, resistin was suggested to be elevated in the subjects with periodontal disease.5.(Nishimura F) Infection by P. gingivalis was associated with elevated LDL-cholesterol. This appeared to be accompanied by increased cholesterol synthesis, which was induced by up-regulation of HMG-CoA mRNA level by TNF-a and IL-6 produced by periodontal infection.6.(Watanabe T, Yamamoto T and Tomofuji T) We established experimental rat periodontitis model by topical application of lipopolysaccharide and proteases. In rat periodontitis model, oxidative damage of brain, heart, liver and kidney were found.7.(Shizukuishi S) FomA, F. nucleatum outer membrane protein (OMP) bound to salivary statherin-peptide and induced mucosal and systemic immune responses in mice given with cholera toxin as mucosal adjuvant. Less