Molecular basis of autophagy as a cellular survival strategy

真核细胞通过自噬维持生命，自噬是细胞内多方面的大量降解系统。为了理解自噬作为一种细胞生存策略，我们实现了自噬的分子解剖。在结果中，我们发现Atg16L复合体将Lc3锚定在自噬膜结构上，并且Lc3是完成该结构所必需的。此外，这种结构的形成发生在内质网膜衍生的特殊“摇篮”内。

Eukaryotic cells maintain their life by using autophagy, an intracellular bulk degradation system in the diverse aspects. To understand autophagy as a cellular survival strategy, we achieved molecular dissection of autophagy. In results, we found that Atg16L complex anchors LC3 to the autophagic membrane structure and that LC3 is required for completion of the structure. Furthermore, formation of the structure occurs inside of the special "cradle" derived from the endoplasmic reticulum membranes.