Chemical synthesis of glycans and glycoconjugates for elucidation of their functions in immune and nerve system

糖链和糖偶联物的新的合成方法已被开发出来，并将其应用于复杂生物活性分子的合成，以阐明作用机理。特别是，为了阐明与天然免疫受体的识别，合成了来自细菌的免疫刺激或免疫调节糖偶联物。天然免疫受体的合成配体用于免疫调节。此外，还研究了多聚糖和糖蛋白的生物成像研究，以进行多聚糖的动力学和动力学分析，以揭示多聚糖的未知功能。

New synthetic methods have been developed for glycans and glycoconjugates and applied them to the synthesis of complex bioactive molecules for the elucidation of action mechanisms. In particular, immunostimulating or immunomodulating glycoconjugates from bacteria were synthesized for elucidation of the recognition with innate immune receptors. Synthetic ligands for the innate immune receptors were used for the immune regulation. Bio-imaging studies of glycans and glycoproteins were also studied for the dynamic and kinetic analysis of glycans to unveil the unknown function of glycans.