Establishment of mouse model of carcinomatous peritonitis for tailor maid cancer therapy.

肿瘤干细胞标志物CD44在T3/4型胃癌中的表达。我们探讨CD44表达与晚期T3/4型胃腺癌患者癌性腹膜炎等临床病理因素的相关性。本研究未发现已知肿瘤干细胞标志物CD44的表达与临床病理因素之间存在相关性。然而，即使在晚期（T3-4）胃腺癌患者中，CD44阳性组的预后也比CD44阴性组差。这些结果表明，被认为是癌症干细胞标志物的CD44可能参与了肿瘤的进展，尽管其确切机制仍有待阐明。

Cancer stem cell marker CD44 expression in T3/4 gastric cancer.We investigated the correlation between expression of CD44 and clinicopathological factors such as carcinomatous peritonitis in patients with advanced T3/4 gastric adenocarcinoma. Present study did not show any correlation between the expression of CD44, known cancer stem cell marker, and clinicopathological factors. However, even among patients with advanced (T3-4) gastric adenocarcinoma, CD44 positive group showed poorer prognosis than CD44 negative one. These results suggested that CD44, putative cancer stem cell marker, might be involved in tumor progression, although the precise mechanism remains to be elucidated.