Gene interaction of morphogenesis for gutter-shaped root

本研究以C57L/J品系小鼠（LJ小鼠）和C57BL/6J品系小鼠（B6小鼠）为研究对象，探讨影响牙根形成的基因。我们采用免疫组化（IHC）方法分析了sonic hedgehog（SHH）和GLI1 - kruppel家族成员GLI1（GLI1）在出生后10、11、12天的表达模式。SHH和Gli1在LJ小鼠和B6小鼠牙根分叉区表达模式存在差异。提示SHH信号通路参与C57L/J品系小鼠牙根形成。

The aim of this study was to identify the gene for influencing to tooth root form using C57L/J strain mice(LJ mice) and C57BL/6J strain mice(B6 mice). We performed immunohistochemistry(IHC) to analyze the expression patterns of sonic hedgehog(SHH) and GLI-Kruppel family member GLI1(Gli1) in postnatal days 10, 11, 12.Expression patterns of SHH and Gli1 showed differences in tooth root bifurcation area between LJ mice and B6 mice. It is suggested that SHH signaling pathway is involved to tooth root formation in C57L/J strain mice.